Car hire
San Francisco Mission District
Additional Information
Your way to SIXT/By car
From SFO Airport:
Head northwest on US-101 N (for 10 miles). Take exit toward Cesar Chavez St/Potrero Ave (0.2 miles). Use the left lane to merge onto Bayshore Blvd. Use the left lane to take the Cesar Chavez St ramp. Keep left at the fork, follow signs for Cesar Chavez St. Turn right onto Hampshire St. Turn left onto 26th St. Turn right onto S Van Ness Ave (for 1.1 mile). The SIXT branch will be on your right.
From Golden Gate Bridge 101 S:
Head southeast on US-101 S. Use the right 2 lanes to take exit 437 for Marina Blvd toward Presidio. Keep right at the fork to continue toward Girard Rd. Turn left into Lincoln Blvd. Turn left into Pacific Ave. Turn right on Lyon St. Turn left onto Bush St. Turn right onto Gough St (use the left 2 lanes to turn slightly left to stay on Gough St). Turn left onto 13th St. Turn right onto S Van Ness Ave. The SIXT branch will be on your left.
From East Bay Interstate 80:
Head south on Us-101 S. Take exit 432 for C Chavez St. Keep right at the fork, follow signs for C Chavez St W. Keep left, follow signs for Cesar Chavez St W. Turn right onto S Van Ness Ave. The SIXT branch will be on your right.
From Palo Alto:
Head northwest on Middlefield Rd toward Embarcadero Rd. Turn right onto Embarcadero Rd. Use the right lane to take the ramp to SF. Keep left, follow the signs towards SF and merge onto US-101N (for 29 miles). Take the exit toward Cesar Chavez St ramp. Keep left at the fork, follow signs for Cesar Chavez St. Turn right into Hampshire St. Turn left onto 26th St. Turn right onto S Van Ness Ave (for 1.1 miles). The SIXT branch will be on your right.
From The Castro:
Head east on 18th St toward Hartford St (for 1 mile). Turn left into S Van Ness Ave. The SIXT branch will be on your right.
Return information
Return Time: All vehicles must be returned by 6 PM Monday through Friday and by 3 PM Saturday and Sunday.
After-Hours Return Options: Return the car to SIXT San Francisco Airport for a $99 charge.
Fees: Return the car the following day during business hours please advise customer additional charges for late returns will apply and be added to the rental agreement.
Directions
37.76542282104492, -122.41730499267578
San Francisco Mission District
Address
475 S Van Ness Ave, San Francisco CA 94103-3629, USA
Business hours
Mon - Fri
08:00 - 17:00
Sat - Sun
08:00 - 15:00
Public Holidays
08:00 - 17:00
4.7
Our customers love us
4.7 stars from 967 reviews at San Francisco Mission District.
Drive Luxury
Rent one of our top luxury models at our San Francisco Mission District branch.
More flexibility
Change or cancel bookings at no extra cost at most of our locations worldwide.
Customer reviews & feedback
4.7
4.6531954
Based on 967 reviews
from our Customer Excitement Score survey*
Listen to what our customers say
4.8
4.8
4.8
LatinCredits J.
5.0
Great service, thanks.
John T.
4.0
I've tried to rent here four times. First time, they swapped cars on me, so I cancelled and went to Avis. I had a particular car in mind for a reason. Second time, I got the car and everything was perfect. Third time, the system didn't send me a confirmation email and the website left me in a "we're searching for your car" loop. Turned out the reservation had gone through, but I cancelled it and tried again. Fourth time, perfect. So, Sixt is batting .500. That being said, the service at the shop was excellent, the car was clean and the value was high. The ease of renting here is why I come back. Blake does a good job handling your rental.
Gladys B.
5.0
Excellent service, punctual and very efficient. Thank you for your work. I received a clean car, with a good smell, and the entire process was very efficient and fast. I arrived on time for my appointment, thanks to your fast service.
*Our Customer Excitement Score is based on a survey sent to all customers who booked at San Francisco Mission District. The score is an average of all customer responses.
Good to know when renting at San Francisco Mission District
What's the minimum age to hire a car at San Francisco Mission District?
To rent a car with SIXT at San Francisco Mission District you need to be at least 21 with a valid license. Some car categories have a higher minimum rental age, and an underage driver fee may apply.
Can I modify, extend, or cancel my reservation?
You can modify, extend, or cancel your reservation in San Francisco Mission District through your manage booking section or through the app.
What documents do I need to hire a car at San Francisco Mission District?
You need a valid driver’s license held for at least 1 year, depending on the car category. You might also need an International Driving Permit or official translation of the license.
Easily book a long-term rental at San Francisco Mission District by entering trip dates and pick-up/drop-off locations.
A damage waiver is included with your booking. You can add other protection products to reduce your excess.
You can add additional drivers to your booking as an optional extra.
Check out our nearby locations to San Francisco Mission District
Check out one of our nearby branches to San Francisco Mission District where you’ll find the same great service and affordable rates.
© Sixt 2025